Police officers were called to Four Falls exit off Route 130 in the early morning hours after a car going south didn't negotiate the curve, veered off of the road, down a bank, and stopped in the woods.
One man was brought to hospital in Saint John with serious injuries, two were brought to Edmundston hospital with non-life threatening injuries and the fourth person in the car was not seriously hurt.
The four men are between 20 and 25, three from Drummond and one from Saint-André.