Corporal Chantal Farrah says the crash happened around 1am when a vehicle carrying four people, between the ages of 17 and 20, lost control while driving on Route 370 near Tracadie-Sheila.
Farrah says the vehicle lost control on a dirt road in a remote area while trying to go uphill and slipped off the road and into the Tracadie River.
Divers and a search and rescue team are combing the sides of the river, while officials are trying to recover the submerged vehicle.
The province's Transportation Department has provided a plow to clear away a path to the area.
Farrah says road conditions were slippery at the time of the crash.
