RCMP say it happened at 5:20pm on Highway 7 near Petersville, which is located about halfway between Saint John and Fredericton.
The driver, who was the only person in the vehicle, died at the scene. Three of the nine people on the Maritime Bus coach were treated for minor injuries.
What caused the crash isn't yet known, however, the Mounties say heavy rain may have played a role in the collision. They don't believe speed or alcohol are factors.
A collision re-constructionist is helping with the investigation.
